Urinary Micrornas as Noninvasive Biomarkers for Acetaminophen- Induced Liver Injury
نویسندگان
چکیده
منابع مشابه
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Drug-induced liver injury is a frequent side effect of many drugs, constitutes a significant threat to patient health and has an enormous economic impact on health care expenditures. Numerous efforts have been made to identify reliable and predictive markers to detect the early signs of drug-induced injury to the liver, one of the most vulnerable organs in the body. These studies have, however,...
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Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urinary proteins related to acute liver injury induced by acetaminophen (APAP). Mice were given a single intraperitoneal dose of APAP (0-350 mg/kg bw) f...
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ژورنال
عنوان ژورنال: Journal of Postgenomics Drug & Biomarker Development
سال: 2011
ISSN: 2153-0769
DOI: 10.4172/2153-0769.1000101